Letter by Behrouz et al Regarding Article, “Tenecteplase–Tissue-Type Plasminogen Activator Evaluation for Minor Ischemic Stroke With Proven Occlusion”

Letter by Behrouz et Al regarding article, "Tenecteplase-tissue-type plasminogen activator evaluation for minor ischemic stroke with proven occlusion".

BACKGROUND AND PURPOSE Minor stroke and transient ischemic attack with an intracranial occlusion are associated with neurological deterioration and disability. Tenecteplase (TNK-tissue-type plasminogen activator) compared with alteplase is easier to administer, has a longer half-life, higher fibrin specificity, possibly a lower rate of intracranial hemorrhage, and may be an ideal thrombolytic a...

Tenecteplase–Tissue-Type Plasminogen Activator Evaluation for Minor Ischemic Stroke With Proven Occlusion

Among the ≈700 000 ischemic strokes per year in North America, most (≤70%) are minor and initially nondisabling presenting with transient or persistent minor stroke symptoms (transient ischemic attack or minor stroke). However, this seemingly mild presentation is misleading because the prognosis is not benign. Multiple studies have reported that among patients considered too mild for thrombolys...

Letter by Scheitz et al regarding article, "Intravenous thrombolysis in nonagenarians with ischemic stroke".

Letter by El Husseini et al regarding article, "What causes disability after transient ischemic attack and minor stroke?".

Letter by Naoumis et al regarding article, "Sleep apnea in patients with transient ischemic attack and minor stroke: opportunity for risk reduction of recurrent stroke?".

BACKGROUND AND PURPOSE Patients with TIA and minor stroke are at high risk for recurrent stroke. Obstructive sleep apnea (OSA) may increase this risk. The objectives of our study were to determine the prevalence and severity of OSA and its clinical presentation in this population. METHODS Patients who presented with TIA and minor stroke completed a questionnaire and nocturnal cardiopulmonary ...